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March 31, 1969, Vol 207, No. 13 >
ARTICLE | March 31, 1969

MEDICAL NEWS

JAMA. 1969;207(13):2363-2376. doi:10.1001/jama.1969.03150260019003.
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ABSTRACT

Localized O2 Aids Ischemic Limbs  By using a technique of localized hyperoxygenation, investigators have avoided amputation of otherwise incurably ischemic extremities in 40 diabetic patients.Not only have most of the typical lesions accompanying diabetes healed, but a five-year follow-up shows no recurrence of ischemia according to workers at Baylor University Medical Center, Dallas.J. W. Finney, PhD, director of the Baylor Institute for Biomedical Research, reported the results at the 66th Annual Meeting of the American Association of Pathologists and Bacteriologists.Atherosclerosis and capillary basement membrane thickening occur frequently in diabetics, Dr. Finney said. The capillary basement membrane may become thick enough to interfere with tissue perfusion.This problem has been attacked successfully using hyperbaric oxygen, but hyperbaria produces side effects in the lungs and central nervous system.With the localized method developed at Baylor, side effects have been limited to rare instances of vasospasm.A catheter

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