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March 24, 1969, Vol 207, No. 12 >
ARTICLE | March 24, 1969

Allergy to Local Anesthetics

Leo H. Criep, MD
JAMA. 1969;207(12):2283. doi:10.1001/jama.1969.03150250113020.
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ABSTRACT

To the Editor:—  The article, "Allergy to Local Anesthetics (207:356, 1969), suggests that positive immediate wheal and flare type of skin reactions are obtained in patients sensitive to procaine hydrochloride and related drugs, and that "a negative response (skin test) may suggest tolerance to the drugs."The authors state that "the validity of skin testing is not that it gives the total answer to whether or not a patient is allergic to a certain drug; but it is assumed that patients can safely receive the drugs to which they do not respond." Furthermore, the patient whose case history is included in this report had recurrent local and systemic reactions on several occasions following the injection of procaine. The intracutaneous tests were carried out with 0.1 ml of procaine hydrochloride (1%) and similar amounts of related drugs. I should like to comment as follows: (1) Patients truly allergic to a

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