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March 17, 1969, Vol 207, No. 11 >
ARTICLE | March 17, 1969

Ringer

William M. Heller, PhD
JAMA. 1969;207(11):2103-2104. doi:10.1001/jama.1969.03150240123026.
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ABSTRACT

To the Editor:—  Your editorial on Sydney Ringer appeared at a timely moment, as I have just been working on the Ringer's injection monograph for the forthcoming United States Pharmacopeia XVIII. Your editorialist may have quoted Ringer correctly ("one part of dried bullock's blood solution to two parts of saline"), but he fails to quote correctly the current legal standard for Ringer's injection and provides 50% too much calcium chloride in his formula. The correct formula is: sodium chloride, 0.86% (not 0.85%); potassium chloride, 0.03%; and calcium chloride, 0.033% (not 0.048%)—in water for injection.It should be noted also that calcium chloride, as a USP chemical, is the dihydrate; thus the USP formula contains only 0.029% calcium chloride if calculated on the anhydrous basis.Ringer's solution was first admitted to USP XII in 1942, the last year Latin titles were used, under the name liquor chloridum trium isotonicus. The proportion

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