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Marihuana Effects on Sleeping States

Paul W. Frankel
JAMA. 1972;221(10):1166. doi:10.1001/jama.1972.03200230052026.
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To the Editor.—  In a LETTER TO THE EDITOR, "Effects of Marihuana on Sleeping States" (220:1364, 1972), Dr. Frank R. Freemon reported a study with two subjects that led him "to suggest that physiologic withdrawal effects can occur after only four nights of marihuana use." Freemon's conclusion certainly deserves critical analysis because the study concerns a topic of great current interest, and, as he pointed out (p 1364), his conclusion contradicts much recent evidence on the effects of marihuana.Freemon noted his work was only a pilot study, and as such perhaps should not be criticized for its lack of control groups (eg, no placebo group), and its small number of subjects (two) which makes standard statistical analyses impossible. For example, Freemon felt his "REM Latency" measure was his most convincing data. That measure showed a decrease from base line to drugged state in one subject, and an increase in


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