A total of 210 white male state employees, aged 40 to 59, participated in a screening program for risk factors for coronary heart disease, and 19.5% were hyperuricemic, defined as a serum uric acid level of 7.0 mg/100 cc or above (enzymatic spectrophotometric method). These hyperuricemic subjects were compared with nonhyperuricemic subjects on the behavioral variables of age, education, conflict, internal versus external control, perception of change with respect to early and present life situations, job stability, cigarette smoking, and physical activity. The physiological variables considered were blood pressure, serum creatinine values, serum cholesterol levels, and ponderal index. Hyperuricemia was associated with increased perception of change, decreased job stability, greater cigarette smoking, elevated blood pressure, and lower ponderal index. These associations suggest the possibility that changing living patterns, particularly in persons of upward mobility, may be an important contributing factor in hyperuricemia.