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March 10, 1969, Vol 207, No. 10 >

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ARTICLE | March 10, 1969

MEDICAL NEWS

JAMA. 1969;207(10):1801-1814. doi:10.1001/jama.1969.03150230015003.
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ABSTRACT

Heat Enhances Antitumor Response  Regional perfusion as adjunctive therapy for melanomas and sarcomas of the extremities may be enhanced by heating the perfusate blood.By heating the recirculated blood used to carry melphalan to the tumor site, John S. Stehlin, Jr., MD, has obtained pronounced regression in 10 of 12 melanomas that were locally advanced and could not be excised.Extreme caution must be exercised however, since the technique is accompanied by potentially hazardous complications, Dr. Stehlin told Medical News.The rationale for hyperthermia is based upon experimental and clinical evidence that at least some cancer cells are heat sensitive."The remission rate for melanomas obtained by heating the blood is almost double that seen with conventional perfusion techniques," Dr. Stehlin said."It is too early to talk about survival data, but the tumor response both of melanomas and sarcomas is profound."Dr. Stehlin, clinical associate professor of surgery,

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