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February 10, 1969, Vol 207, No. 6 >

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ARTICLE | February 10, 1969

A uthors' Response

Victor A. Drill, MD; David W. Calhoun
JAMA. 1969;207(6):1151-1152. doi:10.1001/jama.1969.03150190073024.
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ABSTRACT

To the Editor:—  Our conclusions differ from those reached in the British studies in two ways: (a) we may differ at some points in the interpretation of their data, and (b) for general conclusions, our reliance on direct studies conducted with the oral contraceptives. These have failed to demonstrate a relationship to the occurrence of thromboembolic disease, and if the conclusions of the British studies were generally correct we should have expected the increased risk to be apparent. Specific points are as follows:

  1. We agree that the specific rate reported by Dr. Vessey and Dr. Doll for idiopathic deep-vein thrombosis is, for various reasons, not comparable with the data which we quote. Achievement of their goal of obtaining direct comparability within their own study, between rates projected for users and nonusers, needs to be questioned carefully.

    As with all retrospective studies of this type, the population, for which the

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