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February 3, 1969, Vol 207, No. 5 >
ARTICLE | February 3, 1969

Intracutaneous Immune Serum Globulin Therapy in Allergic Children

Bettina C. Hilman, MD; R. Faser Triplett, MD; Lloyd V. Crawford, MD; Fred J. Kittler, MD; Daniel H. Mattson, MD
JAMA. 1969;207(5):902-906. doi:10.1001/jama.1969.03150180032007.
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Fifty allergic children with perennial bronchial asthma, aged 14 months to 13 1/2 years, from three separate pediatric allergy clinics were studied by double-blind, single crossover design comparing minute amounts (0.1 ml) of serum immune globulin given intracutaneously with placebo (sterile physiological saline). The immune serum globulin used in the study was of the same lot number and of placental origin. Random permutation tables were used to assign patients to the treatment groups. The clinical responses to immune serum globulin were excellent in 3, good in 15, fair in 20, and poor in 12. The responses to placebo were excellent in 4, good in 17, fair in 19, and poor in 10. It was concluded that there was no significant difference in the effects of immune serum globulin over those of placebo in the management of children with allergy in this study group.

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