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January 13, 1969, Vol 207, No. 2 >
ARTICLE | January 13, 1969

MEDICAL NEWS

JAMA. 1969;207(2):249-264. doi:10.1001/jama.1969.03150150007003.
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ABSTRACT

Drug May Arrest Or Slow ALS  Amitriptyline hydrochloride, a widely-used antidepressant, appears to have been responsible for halting progression of amyotrophic lateral sclerosis for periods up to a year or bringing about temporary remissions in eight of nine patients. Three additional patients discontinued the drug because of minor side effects.The investigators emphasized the preliminary nature of the study; follow-up ranges from only six months to one year.Until now, there has been no effective treatment for the disorder (Lou Gehrig's Disease) which is a uniformly fatal neurologic disease.About as common as multiple sclerosis (40 deaths per million deaths in the population), the disease is characterized by progressive destruction of upper and lower motor neurons. Its cause is unknown, and a respiratory death usually follows one to three years after onset.Amitriptyline was tried, explained investigators from Yale University and the University of Florida, after observing the improvement

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BMJ 2010;341:c5893-c1494.
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