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ARTICLE |

Renal Clearance in Man of Pharmaceuticals Containing Radioactive Iodine:  Influence of Plasma Binding

Frank T. Maher, MD; W. Newlon Tauxe, MD
JAMA. 1969;207(1):97-104. doi:10.1001/jama.1969.03150140049006.
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Renal clearances of diatrizoate sodium I 125 or iothalamate sodium I 125 measure 90% to 100% of simultaneous classic clearances of inulin; clearances of iodohippurate sodium I 131 or iodopyracet I 131 are 84% and 79%, respectively, of simultaneous clearances of aminohippurate sodium. Plasma binding (8% to 27% of diatrizoate sodium I 125 or iothalamate sodium I 125; 64% to 70% of iodohippurate sodium I 131; 29% to 42% of iodopyracet I 131; 7% to 25% of aminohippurate) is revealed by ultrafiltration studies. Binding is labile and dissociable. Correcting clearances of diatrizoate sodium I 125 or iothalamate sodium I 125 for plasma binding yields values exceeding those of insulin clearances. Uncorrected, they are satisfactory substitutes for inulin clearance in man. Clearances of iodohippurate sodium I 131 or iodopyracet I 131 approximate adequately clearances of aminohippurate when carrier iodopyracet is added and the clearances are corrected for plasma binding to provide an estimate of total clearance.

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