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January 6, 1969, Vol 207, No. 1 >

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ARTICLE | January 6, 1969

Inulin Labeled With Chromium 51 for Determination of Glomerular Filtration Rate

Barry J. Materson, MD; Albert E. Johnson; Eliseo C. Perez-Stable, MD
JAMA. 1969;207(1):94-96. doi:10.1001/jama.1969.03150140046005.
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Glomerular filtration rate (GFR) was determined in 12 patients by simultaneous clearance of inulin and inulin labeled with chromium 51 (inulin51Cr). Paired GFRs calculated by the classic C=UV/P formula showed excellent correlation (r±0.995; P<0.001; y =1.01x - 2.03, where y indicates clearance of inulin5Cr, and x indicates clearance of inulin). The clearance ratio was 0.975. Determination of GFR with inulin51Cr proved to be faster, cheaper, and more practical than with inulin. This compound makes GFR determinations readily available for clinical use.

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