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Outcome of Pregnancy After Induced Ovulation Follow-Up of Pregnancies and Children Born After Clomiphene Therapy

Maureen Hack, MB, ChB; Michael Brish, MD; David M. Serr, MB, ChB; Vaclav Insler, MB, ChB; Moshe Salomy, MD; Bruno Lunenfeld, MD
JAMA. 1972;220(10):1329-1333. doi:10.1001/jama.1972.03200100043009.
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Eighty-six women reached at least 20 weeks' pregnancy in 96 instances, after ovulation induced by clomiphene citrate. Although 37 of the women had 44 previous pregnancies, there had been a high pregnancy wastage (70.5%) producing only 13 live infants prior to the successful clomiphene therapy. After clomiphene therapy, pregnancies were normal except for a high incidence of toxemia (16.7%) and a possibly increased incidence of prediabetes. The pregnancies resulted in 88 single and 8 twin births. The total fetal and neonatal loss was 6.7%. The loss of single births (3.1%) included two stillbirth infants of prediabetic mothers. The twin loss of 25% was due to prematurity. The incidence of congenital malformations was within normal limits.


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