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ARTICLE | December 8, 1975

Systemic Antibiotics and Acne

Dan K. Chalker, MD; J. Graham Smith, MD

JAMA. 1975;234(10):1058. doi:10.1001/jama.1975.03260230058028.

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Initially, antibiotics were used in the treatment of acne in the belief that the pustular component represented a secondary bacterial infection. Penicillin and suflonamides were among the first antibacterial agents to be tried, but were found to be ineffective.¹ Tetracycline was introduced by Andrews et al² in 1951 and has gained widespread acceptance among dermatologists as an effective mode of therapy.^3-5 In this month's issue of Archives of Dermatology (p 1630), Akers et al report that 10% of the tetracyclines and 2% of the erythromycines produced in this country are used by dermatologists to treat acne. This form of therapy was questioned, however, in a QUESTION AND ANSWER series in The Journal in 1974.⁶ Responses ranged from "there is as yet no proof that these drugs [tetracyclines] have a beneficial effect" to their use represents "an accepted modality of therapy in indicated cases."

As Akers et

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Chalker DK, Smith J, Jr.. Systemic Antibiotics and Acne. JAMA. 1975;234(10):1058. doi:10.1001/jama.1975.03260230058028.

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