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JAMA. 1972;220(7):907-916. doi:10.1001/jama.1972.03200070005003.
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Evidence shows 'second messenger' (AMP) may have role in psoriasis  The first real clue to the pathophysiology of psoriasis may be emerging from studies being conducted in the Department of Dermatology at the University of Michigan Medical School, Ann Arbor.Dermatologist John J. Voorhees, MD, biochemist Elizabeth Duell, PhD, and dermatologists Lawrence J. Bass, MD, and John A. Powell, MD, reported to the Federation of American Societies for Experimental Biology meeting in Atlantic City that tissue from psoriatic lesions contains less 3′, 5′-adenosine monophosphate (cyclic AMP) than the uninvolved skin of a psoriasis patient or the skin of a normal person.The investigators biopsied the skin of 25 psoriasis patients and 25 normal volunteers. The two groups had been matched for sex. The differences between the cyclic AMP levels were statistically significant, and these findings also held when psoriatic and "normal" skin samples were compared on the basis of


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