The contributors to this volume of the Recent Results in Cancer Research series have reviewed their personal experiences with cancer in children. Most of the observations and data were derived from the work of the Manchester Children's Tumor Registry and include the rarer as well as the common tumors in childhood. The recording of firsthand information in this way permits the authors to correlate clinical management with specific pathology, therapy, and eventual outcome for individual patients. In addition, they frequently quote examples of unusual problems or complications. Since many of these tumors are quite rare the documentation of such experiences is extremely valuable. The authors bring attention to the growing importance of childhood cancer in relation to other pediatric diseases, stating that neoplasms now rank second among causes of death in children.
The chapter on acute leukemia reviews current approaches to chemotherapy reported from various centers in the world, with