0
ARTICLE |

Fetal Hemoglobin and Female Sex Hormones

Alton I. Sutnick, MD; W. Thomas London, MD; Betty Jane S. Gerstley, MD; Veronica E. Zavatone, MD; Anita M. Woodside
JAMA. 1968;206(8):1795. doi:10.1001/jama.1968.03150080075026.
Text Size: A A A
Published online

To the Editor:—  Red cells containing abnormal hemoglobin variants have a shortened survival time in vivo. In such hemoglobinopathies higher levels of fetal hemoglobin (Hgb F) are associated with less severe anemia.1 Fetal hemoglobin has oxygen-carrying capacities similar to normal adult hemoglobin, and one would expect that any maneuver raising Hgb F levels would benefit patients with hemoglobinopathies. The stimulus to Hgb F production is not known, but some clinical observations may be relevant. Fetal hemoglobin levels are higher in females with sickle cell anemia than in males2; they increase during pregnancy, and are elevated in patients with choriocarcinoma.3,4 This suggests that chorionic gonadotrophin, estrogen, or progesterone may promote fetal hemoglobin synthesis.Four female patients, 21 to 32 years old, with hemoglobinopathies were investigated for fetal hemoglobin levels. Three had sickle cell thalassemia and one had sickle cell anemia. Chorionic gonadotrophin was administered to one patient with

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();