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Ethacrynic Acid and Diabetes

Seymour Diamond, MD
JAMA. 1968;206(8):1793-1794. doi:10.1001/jama.1968.03150080073024.
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To the Editor:—  It now appears that we have a series of articles showing a suggested dose response related to the elevation of blood sugar in diabetic patients after being treated with ethacrynic acid. My colleague and I have shown that 100 mg of ethacrynic acid daily does not influence the carbohydrate metabolism of nondiabetic or diabetic individuals (Dis Chest51:282-287, 1967). Dige-Peterson has shown that a daily dose of 150 mg of ethacrynic acid does not alter carbohydrate metabolism. In an excellent article, Russell et al (JAMA205:81, 1968) have shown that the high maintenance dose of 200 mg daily alters the carbohydrate metabolism in diabetics when compared to a placebo medication but not to their control periods. The nondiabetogenic individuals did not show the above alteration. These studies certainly indicate that ethacrynic acid is a valuable and safe drug, even in the diabetic patient. They do


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