Hepatic Injury Related to Tromethamine

Gabriel G. Nahas, MD
JAMA. 1968;206(8):1793. doi:10.1001/jama.1968.03150080073022.
Text Size: A A A
Published online

To the Editor:—  The paper by Goldenberg et al (205:81, 1968) describing liver damage in infants receiving concentrated tromethamine (THAM) solution (1.2M, pH 10.2) through the umbilical vein confirms previous observations. Indeed, a review of the literature concerning the effect of the infusion of hypertonic alkaline solutions indicates that such administration does produce liver damage. Brinkman et al1 reported in 1961 that administration of 1.5M tromethamine (pH 10.2) in a diabetic patient who subsequently died presented hydropic degeneration of liver cells as well as kidney. In 1963, it was reported that fetal rhesus monkeys treated by injection of sodium carbonate (pH 10.5, 0.7M solution, 2,100 mOsm) into the umbilical vein were found to have liver damage at the time of postmortem examination.2 This damage was described as areas of hemorrhage with necrosis of liver cells. By contrast, diabetic patients treated with tromethamine (0.3M) did not present any microscopic


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.