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Vitiligo and Multiple Glandular Insufficiencies

Manuel M. Villaverde, MD
JAMA. 1972;220(3):420. doi:10.1001/jama.1972.03200030078034.
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To the Editor.—  The paper on "Vitiligo and Multiple Glandular Insufficiencies," by McGregor, Katz, and Doe, calls attention to the association of vitiligo with many other pathological conditions (219:724, 1972). In 1954, I published the first of a series: "Combinación sindrómica diabetes-vitiligo" (Diabetes-vitiligo Syndromic Combination),1 emphasizing a possible hypophyso-hypothalamic inductive mechanism since the clinical manifestations of the patients were manifold. Together with diabetes and vitiligo there were found cases with goiter, obesity, prostatic adenoma, hypertension, myxedematous heart disease, rheumatoid arthritis, and several others.Lately, following Dawber's report on the increased incidence of vitiligo among diabetic patients, a new paper was published in England to make these facts known to the American physicians,2 which McGregor et al did not see. This is a totally new clinical problem involving a mechanism which may also induce other clinical associations.


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