Treatment of Gonorrhea

H. Hunter Handsfield, MD
JAMA. 1972;220(3):419-420. doi:10.1001/jama.1972.03200030077032.
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To the Editor.—  The major conclusions drawn by Neumann and Baecker (219:471, 1972)—that tetracycline and its derivatives are as effective as penicillin and are currently the drugs of choice in the treatment of acute uncomplicated gonorrhea, and that penicillin should be "saved" for more serious infections—are not supported by the data presented.The follow-up of only 35% of this small series is insufficient to allow meaningful interpretation of the treatment results. It is impossible to determine how many nonreturnees missed their appointments because of symptomatic cure, and how many missed because lack of improvement or early relapse led them to seek care at another facility. Also important is the well-documented conversion of symptomatic urethritis to an asymptomatic but still communicable carrier state by suboptimal treatment.1 Some of the returnees were not examined with use of cultures and the method of obtaining the urethral cultures in asymptomatic patients is


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