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Tetracycline for Gonorrhea

James C. Cobey, MC
JAMA. 1972;220(3):419. doi:10.1001/jama.1972.03200030077031.
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To the Editor.—  This is in reference to the article by Neumann and Baecker (219:471, 1972) recommending tetracyclines for treatment of gonorrhea. Though tetracyclines may be effective and eliminate the danger of anaphylactic shock, we have often found poor results using oral medication, such as tetracyclines, because of patient noncompliance. Time and time again at the Venereal Disease Clinic of the Preventive Medicine Service of Madigan General Hospital, treating permanent party personnel as well as South Viet Nam returnees, in spite of receiving careful instruction, the patient receiving oral medication will take half the dose and give half to his girl friend, resulting in treatment failure.Though microbiologically orally taken tetracyclines may be very effective, socially it has met with many failures. We strongly recommend one-shot therapy for gonorrhea of procaine penicillin, 4.8 million units with 1 gm of probenecid (Benemid) administered 30 minutes prior to treatment, followed by


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