0
ARTICLE |

Delayed Hypersensitivity

Max Samter, MD
JAMA. 1968;206(7):1577. doi:10.1001/jama.1968.03150070115037.
Text Size: A A A
Published online

ABSTRACT

"Delayed hypersensitivity" is an inflammation produced by small lymphocytes which—after sensitization to certain antigens—attack these antigens when they persist or return. Such antigens include small chemicals attached to carrier molecules, bacterial fragments, homografts, and heterografts.

Fifty years ago, the function of lymphocytes was unknown; we know now that they are guardians of our integrity as a species. The small lymphocyte, the subject of this volume, not only carries the immunological memory of the host and instructs large lymphocytes to produce antibodies when antibodies are essential for survival, but it also has specific functions of its own. Small lymphocytes participate, as cells, in immunological reactions; unlike large lymphocytes, they do not release their antibodies, but carry them to the site of contact with the antigen.

The book raises fundamental questions which are carefully worded, and provocative. Is it possible, for instance, to transfer sensitized small lymphocytes and, thus, delayed sensitivity from

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();