Cytomegalovirus Complement-Fixation Antibody Levels of Leukemic Children:  Results of a Longitudinal Study

Margaret P. Sullivan, MD; James B. Hanshaw, MD; Ayten Cangir, MD; James J. Butler, MD
JAMA. 1968;206(3):569-574. doi:10.1001/jama.1968.03150030025005.
Text Size: A A A
Published online

Initial cytomegalovirus complement-fixation antibody titers were positive in two of 16 leukemic children (12%) who had received chemotherapy for less than one month. Longitudinal titer determinations in this group showed nine seroconversions, the median time for seroconversion being two months. Illnesses suggestive of viral infection preceded seroconversion in four children. Fulminating, life-threatening pneumonitis developed in one child, who was treated with floxuridine. Antibody titers of initial sera were positive in 12 of 25 children (48%) receiving chemotherapy more than one month. In this second group of children, fluctuations in established titers showed no correlation with clinical events. Further studies are needed to elucidate the pathogenesis of cytomegalic inclusion disease which may be fatal, in transplant recipients and chemotherapy patients experiencing immunosuppression.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.