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Hematuria and Cholethiasis With β-Thalassemia

Mason G. Robertson, MD
JAMA. 1972;219(9):1213. doi:10.1001/jama.1972.03190350049025.
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To the Editor.—  Since the report of Goodwin et al1 in 1950 of painless hematuria associated with sickle cell hemoglobinopathy, numerous reports have confirmed the phenomenon in both sickle cell (SS) trait and SS disease.Gunnels and Grim2 have reported painless hematuria in A/D hemoglobinopathy. We have previously reported a case of recurrent painless hematuria in a patient with hemoglobin C trait.3 The present report concerns a child with painless hematuria who had β-thalassemia trait associated with silent gall stones.A 5-year-old black American child was found on routine preschool examination to have significant microscopic hematuria. Complete urological evaluation revealed no abnormality but x-ray films showed radiopaque gall stones. Results of hematological evaluation included a hemoglobin level of 10.8 gm/100 ml, normal bilirubin level, and normal reticulocyte count. Hemoglobin electrophoresis however revealed an A2 hemoglobin value of 4.3%. Analysis of the parents revealed normal hematograms for both


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