Allergy to Fluoride

George E. Shambaugh Jr., MD
JAMA. 1972;219(9):1212. doi:10.1001/jama.1972.03190350048023.
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To the Editor.—  Commenting on the question of allergy to fluoride, I have utilized fairly large doses, from 40 to 120 mg daily, for patients with active spongification of the cochlear capsule to promote recalcification. A total of 1,500 patients have been treated to date for periods of six months and up to four years. Any untoward reactions or symptoms are reported and recorded. In only three cases to date has there occurred a typical drug rash which cleared when the medication was stopped, and recurred when it was resumed.Since allergic reactions can occur with minute amounts of allergen, it is, of course, possible that similar reactions could occur with very small amounts of fluoride. If so, we should expect patients in high-fluoride areas to develop sensitivity, and as far as I know, this does not occur. Even though allergy to fluoride can occur, it is rare, and as


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