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Evaluation of an Interferon Inducer in Viral Respiratory Disease

David A. Hill, MD; Samuel Baron, MD; John C. Perkins, MD; Michael Worthington, MD; John E. Van Kirk, MD; John Mills, MD; Albert Z. Kapikian, MD; Robert M. Chanock, MD
JAMA. 1972;219(9):1179-1184. doi:10.1001/jama.1972.03190350025006.
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To evaluate the effect of an interferon inducer on respiratory tract virus infection, poly l.poly C was administered intranasally to volunteers for a seven-day period beginning one day prior to inoculation of rhinovirus 13 or type A2 influenza virus/Hong Kong/68. In three separate trials, toxic effects were not detected and there was a small, but definite, reduction in symptoms of upper-respiratory tract illness associated with drug treatment. However, there was a variable effect on the pattern of virus infection. In only one of the two rhinovirus studies was a reduction of virus shedding observed. Treatment did not decrease the shedding of type A2 influenza virus. The minimal amounts of nasal interferon stimulated by the intranasally administered poly l.poly C may have been responsible for the less-than-optimal results obtained.


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