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Acute Lymphoblastic Leukemia And Histiocytic Medullary Reticulocytosis

Vaughan P. Simmons, MD
JAMA. 1975;233(12):1258. doi:10.1001/jama.1975.03260120020006.
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To the Editor —  Dr David Shreiner's article was very interesting and has stimulated me to make the following comments.The chest roentgenogram showed an anterosuperior mediastinal mass that varied in size from time to time. The nature of the mass and its origin were not defined except to indicate that the mass was composed of malignant histiocytes. I suggest that the mass may have been of thymic origin and that it was the source of the abnormal cells, rather than a depository for them.1-3The illustrations of "erythrophagocytosis" may represent such a phenomenon, but I call attention to the possibility that the globules may not be red blood cells at all, but retained or phagocytosed glycoprotein globules secreted by these cells or others of the plasma cell line.The similarity of such globules to red blood cells has often deceived me and confused many other investigators in the


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