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Addiction to Daprisal

John A. Sours, MD
JAMA. 1968;205(13):940. doi:10.1001/jama.1968.03140390064026.
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To the Editor:—  Although addiction to amphetamine has been well known since 1958 when Connell1 first published his clinical studies on amphetamine usage and amphetamine psychosis, addiction to Daprisal, a combination of amobarbital (32 mg), dextroamphetamine sulfate (5 mg), aspirin (0.16 gm), and phenacetin (0.16 gm), has only been recently appreciated.2 Daprisal is generally regarded as a moodlifting analgesic for the relief of pain, prescribed for dysmenorrhea, pain of arthritis, rheumatism, headache, neuralgia, and nonspecific muscular disorders. The drug has become popular for the treatment of dysmenorrhea. The high risk of amphetamine dependency for young women has not been sufficiently emphasized.Lemere has mentioned Daprisal as an amphetamine-containing preparation with a likelihood of highdependency risk.3 Ehtishamuddin has reported an addiction in a depressed woman who was taking six to eight tablets daily for several years.4 Johnson and Milner have reported one case of addiction to this


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