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Trimethoprim-Sulfamethoxazole Therapy for Prostatitis

Edwin M. Meares Jr, MD; Thomas A. Stamey, MD
JAMA. 1975;233(10):1048-1049. doi:10.1001/jama.1975.03260100018009.
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To the Editor.—  The article by Donald O. Schiffman (231:635, 1975) describes the new antibacterial combination drug, trimethoprim-sulfamethoxazole (Bactrim, Septra) and in passing cites its usefulness in the therapy of prostatitis. If physicians are to use trimethoprim-sulfamethoxazole in treating prostatitis, we feel compelled to share our observations regarding the use of this drug in treating chronic bacterial prostatitis.In general, two major types of chronic prostatitis are clinically recognized today: chronic bacterial prostatitis, where a specific bacterial pathogen can be identified by proper culture techniques, and nonbacterial prostatitis, where no pathogen can be isolated.1 The latter condition is the more common of the two types, is not associated with bacteriuria, and does not respond to antibacterial therapy, including trimethoprim-sulfamethoxazole. Chronic bacterial prostatitis, however, is probably the most common cause of relapsing urinary tract infection in men.2 Since the treatment of the two conditions is entirely different, bacteriologic localization

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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