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Metabolic and Endocrine Physiology: An Introductory Text

T. Albert Farmer Jr., MD
JAMA. 1968;204(12):1150. doi:10.1001/jama.1968.03140250130030.
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The attempt by a single author to prepare a 250-page volume reflecting balance of the rapidly developing knowledge in the area of metabolic and endocrine physiology is both a herculean and admirable task.

As a physician involved with the teaching of endocrinology and metabolism to undergraduate medical students, I am in agreement with the author that "the study of Endocrinology can be viewed as one long exercise in correlation." However, it is in this area of correlation that this volume falls short of its goal. The statements that certain clinical conditions result because hormones are being metabolically inactivated at too slow a rate, that Simmonds' disease is a genetic or developmental defect in early childhood, that adrenal 21-hydroxylase defect is without disturbances in water and electrolyte metabolism, that metyrapone (Metopirone) is an experimental drug with clinical application not yet widespread, that desoxycorticosterone acetate causes hypertension without expansion of circulating blood


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