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Intensive Antibiotic Treatment for Burns Complicated by Pseudomonas Infection

Hiram C. Polk Jr, MD
JAMA. 1968;204(12):1148. doi:10.1001/jama.1968.03140250128025.
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To the Editor:—  The stimulating report by Collentine et al (200:939, 1967) concerning the use of intensive antibiotic therapy and exposure for hospitalized burn patients included a statement that Pseudomonas septicemia had not occurred since the addition of prophylactic intravenously administered polymyxin B sulfate to their treatment regimen. Although our treatment program emphasizing topical antisepsis with 0.5% aqueous silver nitrate had improved burn survival significantly,1 invasive Pseudomonas infection remained a major threat to our most badly burned patients.2 Accordingly, alternate patients sustaining second and third degree burns of 40% of the body surface area or greater received a "prophylactic" regimen of intravenously administered polymyxin B sulfate as described by Collentine et al. This group represented those individuals with a reasonable likelihood of acquiring Pseudomonas infection. The patients treated and not treated were similar as to age distribution, extent of burns, and proportion of full thickness burns, all


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