We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Thioridazine in Schizophrenia

Bruce E. Carlson, MD; Robert L. Sadoff, MD
JAMA. 1971;217(12):1705. doi:10.1001/jama.1971.03190120071024.
Text Size: A A A
Published online


To the Editor.—  At Norristown (Pa) State Hospital, we have had considerable experience in the use of thioridazine (Mellaril), primarily with schizophrenics, but also with patients with nonpsychotic severe anxiety reactions. It is well known that thioridazine, because of its adrenolytic activity, inhibits or prevents ejaculation in some patients. Though not specifically dose-related, this phenomenon is generally more severe at higher dosages.Thioridazine has been shown to cause impotency in males and delay of orgasm in both men and women. Occasionally, thioridazine has been found to be effective in the treatment of premature ejaculation, prolonging the time between insertion and ejaculation. The exact basis of this effect is unknown but may be related to decrease in anxiety or a specific chemical effect on the sexual functioning.Schizophrenics, generally, are most disturbed by any changes in bodily function, whatever the cause, but especially in their sexual functioning. With the use of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.