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JAMA. 1971;217(5):543-552. doi:10.1001/jama.1971.03190050005003.
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ABSTRACT

Sodium fluoride bone scans complement x-rays in staging lymphomas  A radionuclide technique that helps in the staging of lymphomas by determining the extent of their bony spread was described at the recent meeting of the Society for Nuclear Medicine in Los Angeles.Sloan-Kettering Memorial Cancer Center investigators stressed, however, that roentgenograms remain essential "to detect the occasional lesion that is missed by the bone scan."The radionuclide used in sodium fluoride F 18, was found a few years ago to be superior to strontium 85 and calcium 47 for bone scanning. The radionuclide has been administered to over 500 patients at Sloan-Kettering, according to Richard S. Benua, MD, chief of Memorial Hospital's nuclear medicine service. The radiation dosage is considerably less than that given by a typical roentgenogram.The key to sodium fluoride's activity is that it replaces hydroxyl ions in bone. Apparently this process tends to be enhanced

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