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JAMA. 1968;203(11):23-36. doi:10.1001/jama.1968.03140110099046.
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Direct Attack On Cerebral Gliomas  The frustrating clinical problem of deep cerebral gliomas has led a Boston neurosurgeon to attempt an "inside-out" chemotherapy approach using a formerly ineffective agent.The revised approach to intracerebral brain tumors was described at a recent New York Academy of Sciences symposium by Bertram Sei verstone, MD. He is professor of neurosurgery at Tufts University School of Medicine and neurosurgeon-in-chief, New England Medical Center Hospitals.Less than a dozen patients with both resected and deep, inoperable tumors have thus far undergone the procedure, Dr. Selverstone said. It may be a year before the clinical effect can be evaluated.Based on several years of animal and in vitro experiments, the Boston physician and colleagues decided to attempt massive chemotherapy with the experimental and highly cytotoxic agent, 8-azaguanine. First synthesized in 1945, the drug has previously been "without noticeable effect" when given systemically or intrathecally in


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