0
ARTICLE |

MEDICAL NEWS

JAMA. 1968;203(11):23-36. doi:10.1001/jama.1968.03140110099046.
Text Size: A A A
Published online

ABSTRACT

Direct Attack On Cerebral Gliomas  The frustrating clinical problem of deep cerebral gliomas has led a Boston neurosurgeon to attempt an "inside-out" chemotherapy approach using a formerly ineffective agent.The revised approach to intracerebral brain tumors was described at a recent New York Academy of Sciences symposium by Bertram Sei verstone, MD. He is professor of neurosurgery at Tufts University School of Medicine and neurosurgeon-in-chief, New England Medical Center Hospitals.Less than a dozen patients with both resected and deep, inoperable tumors have thus far undergone the procedure, Dr. Selverstone said. It may be a year before the clinical effect can be evaluated.Based on several years of animal and in vitro experiments, the Boston physician and colleagues decided to attempt massive chemotherapy with the experimental and highly cytotoxic agent, 8-azaguanine. First synthesized in 1945, the drug has previously been "without noticeable effect" when given systemically or intrathecally in

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();