We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......


JAMA. 1968;203(11):977-978. doi:10.1001/jama.1968.03140110069017.
Text Size: A A A
Published online


Normal coronary arteriographic findings are interpreted by most clinicians as evidence that coronary heart disease is absent. However, a recent report by James1 emphasizes the clinical significance of abnormal changes in coronary arteries which are too small to be interpreted adequately even on optimal quality coronary angiograms. Diseases which may damage and occlude small coronary arteries can be classified in three broad categories: embolic, inflammatory, and noninflammatory. Diverse processes including coronary atherosclerosis, multiple platelet aggregation, postoperative particulate debris, and subacute bacterial endocarditis may be responsible for embolic occlusion of small coronary arteries with resultant alteration of cardiovascular function. Small coronary vessel arteritis has been demonstrated in inflammatory diseases such as polyarteritis nodosa, systemic lupus erythematosus, and rheumatoid arthritis. Finally the clinician must be alert to the possibility that noninflammatory disease can significantly affect small coronary arteries; in this group are such pathologic states as amyloidosis, hematologic disorders, diabetes mellitus,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.