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Genetics of Hyperuricemia And Achievement

Harold Schwartz, MD
JAMA. 1967;202(9):913-914. doi:10.1001/jama.1967.03130220101028.
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To the Editor:—  Recent investigations correlating hyperuricemia with achievement have been prompted by the relatively frequent occurrence of gout among the eminent in history.1-3 A genetic family evaluation is a logical extension of the clinical studies.Particularly suitable for consideration are the Harrisons of Virginia who for ten consecutive generations in this country have occupied high elective public office. Among these and the equally eminent cognate line of Lee, several cases of acute gouty arthritis have been documented. Already published but uncorrelated historical data permit genetic association and analysis.4,5A high serum urate level is characteristic of noninvolved members of families where gout is manifest. Also, such arthritis is known to occur in relatively few individuals with familial hyperuricemia. Achievement, leadership, range of activity, and drive correlate with elevated serum urate levels, this being established in university professors, military personnel of high intelligence, medical students, and executives.1,2

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