We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......


Louis Lasagna, MD
JAMA. 1975;232(9):906. doi:10.1001/jama.1975.03250090010003.
Text Size: A A A
Published online


To the Editor.—  I should like to respond to Goldberg's rebuttal (232:143, 1975) to our commentary, "The FDA, Politics, and the Public" (232:141, 1975). To begin with, Wardell and I are certainly not arguing that the Food and Drug Administration (FDA) should approve labeling for uses of new drugs as soon as these uses gain acceptance in current medical practice and in the literature. As Goldberg recognizes in some of the quotations attributed to me, I do not believe that there is a necessary relationship between actual and optimal clinical usage. Where Goldberg and I disagree, however, is in regard to what is "substantial evidence," who is to decide what is substantial evidence, and whether such substantial evidence exists for the use of propranolol in anginal patients.Distinguished and experienced clinicians all over the world have been impressed not only by the available literature on the use of propranolol in


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.