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Pathophysiological and Clinical Aspects of Lipid Metabolism

Kang-Jey Ho, MD; C. Bruce Taylor, MD
JAMA. 1967;202(6):555. doi:10.1001/jama.1967.03130190161046.
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The first part of this symposium discusses lipid metabolism in normal and in pathological conditions —hyperlipemia, atherosclerosis, and coronary heart disease. One of the most interesting subjects is the mechanism of fatty acid mobilization by hormones and by drugs. A round table discussion on the significance of plasma factors in the pathogenesis of atherosclerosis gives much attention to the lipoprotein, especially the de novo synthesis of lipid in the arterial wall and infiltration of lipid from the lumen through the arterial wall. Another round table discussion on the prophylaxis and treatment of atherosclerosis deals with the timely and currently popular topics of dietary composition and calories, and some hypocholesterolemic drugs such as niacin and arachidonic acid. Some other aspects of systemic, cerebral, and peripheral atherosclerosis such as genetic factors, epidemiology, blood coagulation, and histochemical study are also included.

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