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Hypercalcemia and Unilateral Nephrocalcinosis

Hiroo H. Advani, MD; Gurdip S. Sidhu, MD
JAMA. 1975;232(2):161-162. doi:10.1001/jama.1975.03250020035022.
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PERSISTENT hypercalcemia is frequently associated with widespread metastatic calcification, most commonly in the kidneys, lungs, gastric mucosa, and blood vessels. This selective localization is believed to be due to unique physiological factors. Major pathological alterations in the function of these tissues may be expected to alter the distribution of calcium salt deposition. We are reporting a case in which nephrocalcinosis was largely confined to one kidney. It is our opinion that differences in the state of tubular glomerular function are responsible for this differential localization of calcium.

Report of a Case  A 51-year-old man was admitted to the New York Veterans Administration Hospital in August 1973 because of weight loss and pain in the lower back and left thigh, of several months' duration. Transurethral resections on two occasions and finally a partial cystectomy in September 1972 were performed for a transitional cell carcinoma of the urinary bladder diagnosed by cystoscopic


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