0
ARTICLE |

Azathioprine in Refractory Idiopathic Thrombocytopenic Purpura

Leon N. Sussman, MD
JAMA. 1967;202(4):259-263. doi:10.1001/jama.1967.03130170059006.
Text Size: A A A
Published online

Acute idiopathic thrombocytopenic purpura often undergoes spontaneous remission, especially in the young. In patients with chronic conditions complete remissions are unusual. Splenectomy is a recognized therapeutic measure for the cases that fail to remit. However, in about 50% of adults and 10% of children, neither corticosteroids nor splenectomy is satisfactory. Long-term steroid therapy may have many undesirable and sometimes dangerous side effects. The immunosuppressive drug azathioprine (Imuran) was used in long-term management of refractory idiopathic thrombocytopenic purpura in eight cases. Three patients had undergone splenectomy with no improvement in their condition, and all had long-term corticosteroid therapy previously with occasional disastrous results (diabetes mellitus in two instances, collapsed vertebra in one, and psychic disturbance in another). Following the use of azathioprine, the results in seven of the eight patients were satisfactory.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();