Amantadine Hydrochloride

J. J. Quilligan Jr., MD
JAMA. 1967;202(3):247-248. doi:10.1001/jama.1967.03130160121044.
Text Size: A A A
Published online


To the Editor:—  Recent reports ( 200:943-950, and 201:372-373, 1967) on the antiviral compound, amantadine hydrochloride, effective in suppressing A2 virus strains of influenza in the laboratory and in limited field trials, have raised several points that deserve comment. The remarks directed toward validity of data can be best answered by time and further observations.The basic question that must be asked by each physician prescribing amantadine hydrochloride is whether or not to "prophylactically" suppress influenza. The concept of chemoprophylaxis in the face of so-called sporadic influenza appears untenable. However, a widespread epidemic with increased absenteeism from school, etc, and recovery of strains of A2 influenza that are shown to be sensitive to the action of amantadine should be a clear indication for its use. It must be used in proper dosage and before contact.A significant unanswered question regarding amantadine hydrochloride is how it will act on any new antigenic A type that could emerge and result in the dreadful


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.