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Article |

Immunity of School Children Two Years After Oral Poliomyelitis Vaccination

Martha L. Lepow, MD; George A. Nankervis, PhD, MD; Frederick C, Robbins, MD
JAMA. 1967;202(1):27-31. doi:10.1001/jama.1967.03130140085012.
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A serologic survey of the poliovirus immunity of children in a suburban school system was performed in 1964, two years after a mass oral vaccination program. Approximately 6% of the school children were studied and 96% had antibody titers of 8 or greater to all three types of poliovirus. Antibody levels declined during the two-year period, but only significantly so for types 2 and 3 in children who had not received a booster. Antibody titers to types 2 and 3 poliovirus in children who had been given a booster were significantly higher than those who had not received one. A single feeding of a trivalent live oral poliovirus vaccine resulted in a rise in antibody titer in slightly less than half of the subjects with low type 3 titers.


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