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Osteosclerosis and Plasma Cell Leukemia

Thomas J. Degnan, MD; Arthur Feinberg, MD; Edwin Bassett, MD
JAMA. 1967;201(10):780-781. doi:10.1001/jama.1967.03130100078028.
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To the Editor:—  In a patient who presented with myelophthisic anemia, severe peripheral plasmacytosis developed as a terminal event. At autopsy, severe osteosclerosis and localized plasmacytomas were found. Osteosclerosis is an unusual accompaniment of the plasma cell dyscrasias, and the finding of it tends to discredit the diagnosis of myeloma. Recent studies, however, support the contention that osteosclerosis may occur in myeloma. We postulate that the osteosclerosis may well be a reflection of a myeloproliferative process involving various marrow elements at different times.

Report of a Case:—  A 77-year-old woman was first seen in January 1965 because of progressive weakness and anemia. On physical examination no abnormalities were detected except for pallor of the skin and mucous membranes. Laboratory examination revealed a hemoglobin level of 8.7 gm/100 ml, with normal white blood cell and platelet counts. The peripheral smear revealed the presence of teardrop forms, ovalocytes, and nucleated red blood


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