Fluorouracil-Floxuridine Controversy

Charles G. Moertel, MD; Richard J. Reitemeier, MD
JAMA. 1967;201(10):780. doi:10.1001/jama.1967.03130100078027.
Text Size: A A A
Published online

To the Editor:—  Over the past five or more years, a vast expenditure of funds, both federal and private, and considerable investigator time have been devoted to the study of floxuridine (FUDR). The most intense study and the greatest controversy have revolved about the effectiveness of this chemotherapeutic agent in the palliative treatment of advanced carcinoma of the large bowel. Recently, these efforts reached their culmination in the almost simultaneous publication of the results obtained by two large cooperative groups. Each group administered the drug by the intravenous injection technique, and each stated their results were evaluated by objective criteria. The Central Region of the Clinical Drug Evaluation Program1 made a strong plea for further use of floxuridine in colonic cancer with their astonishing objective regression rate of 59%. Perplexing in contrast is the 4% regression rate reported by the Eastern Cooperative Group in Solid Tumor Chemotherapy.2 This


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.