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Isohemagglutinins in Pooled Plasma

K. B. McCall, PhD
JAMA. 1967;201(7):562. doi:10.1001/jama.1967.03130070082032.
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To the Editor:—  The Journal (198:323, 1966) published "Erythrocyte Sensitization and Anemia Due to Isoantibodies in Lyophilized Pooled Plasma" by Oberman, Barnes, and Ginther.The high titers (both saline and immune) of isohemagglutinins reported by Oberman et al for the lyophilized pooled plasma are indeed surprising, particularly in view of the classical and accepted data1-3 which have demonstrated that if pools are prepared of a sufficient number of serums or plasmas selected indiscriminately, one can be certain that the isohemagglutinin titers of these pools will be extremely low (not over 1:28). In fact, this is considered to be the basis for the requirement, established by the Division of Biologics Standards, National Institutes of Health, that the plasma pool shall contain plasma from not less than eight donors. The technical specifications of the American Association of Blood Banks4 further state,The distribution of the blood groups in each


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