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Temporal Arteritis and Sulfonamide Therapy

Stanford I. Lamberg, MD
JAMA. 1967;201(6):492. doi:10.1001/jama.1967.03130060166031.
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To the Editor:—  With the deluge of new drugs and rapid increase in drug reactions, it is common to assume that an unusual disease is related to a predating medication. This frequency of newly noted drug reactions makes careful documentation essential or medicine soon will be without a pharmacopeia.Lee and Andrews report in "Temporal Arteritis Developing in the Course of Sulfonamide Therapy" that we now have another hazardous drug reaction to blame on sulfonamides (200:720, 1967). Their conclusions seems to me unwarranted. The patient was not rechallenged with the drug, and although a rechallenge would not have been warranted because of potential dangers, it would have constituted the only real proof of cause. The patient did not have a skin rash from the sulfonamide, as he was said to have had with a previous exposure. The sulfonamide was not the only drug he was taking. The patient is


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