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Advances in Anesthesiology: Muscle Relaxants

Leonard F. Walts, MD
JAMA. 1967;201(4):278. doi:10.1001/jama.1967.03130040074039.
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Presently, a large number of investigators are involved in experiments attempting to shed light on the mechanism of neuromuscular block. Practicing anesthesiologists may wish to read a succinct review of some of these publications to enable themselves to evaluate and discuss the recent progress. I can think of no better source than the excellent monograph from the staff of Columbia Presbyterian Hospital. Containing only seven chapters and scarcely 100 pages of text, the book will nevertheless help bring one up to date in a complicated field.

This work is not directed toward clinical use of muscle relaxants. Only one chapter is so oriented. The authors, assuming that the reader has a clinical knowledge of these drugs, delve into more fundamental aspects.

Various chapters deal with the mechanism of production of neuromuscular block, physiologic aspects of the block, chemistry and pharmacology of neuromuscular transmission, genetics, and myasthenia gravis. All but the


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