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JAMA. 1967;201(3):21-32. doi:10.1001/jama.1967.03130030007003.
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The Early Diagnosis Of Aldosteronism  Sufficient clinical experience has been accumulated to confirm that primary aldosteronism is the cause of elevated blood pressure in a significant number of patients previously regarded as essential hypertensives.In the two years since Jerome W. Conn, MD, and his co-workers at the University of Michigan School of Medicine first reported a case of normokalemic primary aldosteronism ( JAMA193:200-206 [July 19] 1965) the Michigan group has screened 184 patients with essential hypertension and found aldosteroneproducing tumors in 14 (7.6%).

Significant Number  "No one anywhere in the world has done enough work yet to know precisely how many people thought to have essential hypertension actually have primary aldosteronism, but it will be a significant number," Dr. Conn told the annual meeting of the Canadian Medical Association.Since hypertension in most patients with primary aldosteronism is cured or substantially alleviated by surgical removal of the


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