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In Situ Lobular Carcinoma:  A Prospective Follow-Up Study Indicating Cumulative Patient Risks

Robert W. McDivitt, MD; Robert V. P. Hutter, MD; Frank W. Foote Jr., MD; Fred W. Stewart, MD
JAMA. 1967;201(2):82-86. doi:10.1001/jama.1967.03130020028006.
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In situ lobular carcinoma is a preinvasive form of breast cancer which if inadequately treated will frequently progress to infiltrative cancer. A follow-up study of 50 patients with in situ lobular carcinoma, treated in most instances by local excision, reveals the following subsequent cumulative risk of infiltration: 8% after five years, 15% after ten years, 27% after 15 years, and 35% after 20 years. After 23 years, the cumulative risk is thought to exceed 50%. In addition, the cumulative risk of cancer developing in the breasts contralateral to those in which in situ lobular carcinoma was found was 10% after ten years, 15% after 15 years, and 25% after 20 years. The cumulative risk of contralateral breast cancer after 22 years appears to exceed 30%.


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