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JAMA. 1967;201(1):A23-A38. doi:10.1001/jama.1967.03130010007003.
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Huge Diet-Heart Study Proposed  One of the largest epidemiologic studies in history, designed to find out whether premature coronary artery disease can be prevented by diet, was recommended at the American Medical Association's annual meeting.The proposed study would involve 40,000 to 100,000 men. It would last five years.The cost might range as high as $50 million.The study should be planned and put into operation as soon as possible, the principal investigators of the National Diet-Heart Study said. That study, carried out over approximately two years with about 2,400 men aged 45 to 54 years, was a feasibility trial for the larger investigation now proposed.In recommending the larger study to the National Heart Institute, the funding agency, the investigators said:

  • "The incidence and mortality of premature coronary heart disease in the United States is extremely high... and constitutes one of the greatest challenges to preventive


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